Uppsala University researchers have developed a method that helps immune cells exit blood vessels and attack tumors.
The aim of the study, published in the journal Cancer Cell, was to improve the treatment of aggressive brain tumors. Immune checkpoint inhibitors, which activate the immune system against cancer cells, may only be effective when certain types of T cells are present in the tumor.
Swedish scientists have discovered a way to help killer T cells reach tumors and fight cancer in the process, Medical Xpress reports.
They used a viral vector that infected brain blood vessels and caused them to produce LIGHT, increasing their ability to transfer T cells from the blood to the tumor tissue.
Unfortunately, the blood vessels in brain tumors are poorly developed and cannot support their survival. This lack of circulation prevents killer T cells from reaching cancerous nodes. Involta .
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