Police say the crash happened on I-55 south of Springfield in central Illinois.
The coroner’s office confirmed that at least six people were killed in the crash and more than 30 people were injured, who were taken to hospital.
Britain’s ‘Sky News’ network quoted a police officer as saying the accident was caused by a collision between 40 and 60 cars and trucks.
Police attributed the cause of the crashes to high winds that blew through the area and carried dirt and dust from farm fields across the highway, causing poor visibility.
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